Screening, Diagnosing, and Monitoring Breast Cancer
Focusing on the NO.1 Disease Affecting Women’s Health

One out of ten women will suffer from breast cancer in her life
In developed countries, 1/3 of woman cancer patients are breast cancer related
In China, breast cancer is a dramatically growing disease, and is the No.1disease in urban women population
Early detection is a critical step for disease treatment and for improving women’s life quality

Early Detection, Early diagnosis, Early Treatment.
Key to Women’s Health and Life.

OPTIMUS system is developed on the basis of an innovative technology protected by several US and Chinese patents

OPTIMUS is the result of a combined research and development effort by the University of Connecticut and MDT since 1998

This effort has been supported by a variety of resources including the Connecticut Innovative Fund, NIH grants, Hartford Hospital, and the Health Center of the University of Connecticut

As an innovative technology, it has been shown in the media like Laser World Magazine, Radiology Magazine,and featured in television programs on CBS

Localization- Uses ultrasound imaging to localize tumors, which offers good spatial resolution, and can detect breast lesions of a few millimeters in size. OPTIMUS takes advantage of this technology to localize tumors
Identification- Optical tomography is used to indicate the likelihood of tumor malignancy, a new technique that employs diffused light in the near infrared spectrum, provides functional images of tumor angiogenesis and tumor hypoxia. OPTIMUS utilizes such functional information to indicate the likelihood of tumor malignancy
Early Detection- OPTIMUS can detect and diagnose lesions as small as 0.5cm in diameter
Non-invasive- OPTIMUS performs breast imaging with non-compression, non-radiation, and non-invasive

Tumor Angiogenesis
In 1994, the Angiogenesis Foundation identified angiogenesis as the “common denominator” in important diseases, including breast cancer. Research has shown that solid breast tumors become clinically relevant once they develop a blood supply. Subtle vascular changes are often associated with breast cancer in its earliest stages. Recent technology detects vascular changes and forms a vascular profile to indicate the early vascular zed lesion.

Detection with Multi-Wavelength – OPTIMUS employs multi-wavelength DOT scan to measure HBO2 AND Deoxy HB and calculate hemoglobin concentration and tumor hypoxia

Probe Design – With unique NIR probes for functional imaging design, OPTIMUS images reflect optical diffusion status in different tissue positions

OPTIMUS combines the advantages of ultrasound imaging and DOT imaging to provide diagnostic information on breast lesions

Ultrasound imaging demonstrates structural changes and anatomy of breast tissues, allowing doctors to analyze a multiplicity of conditions and assess lesions

OPTIMUS imaging provides functional information on breast tissues, and reveals the concentration of hemoglobin and oxygen saturation, which are directly related to angiogenesis of lesion

Ultrasound Imaging – Uses the probe in the same way as a regular. ultrasound imaging to locate lesion or areas of interest, and acquire an image
Laser Scan – Uses multi-wavelength laser scan to acquire optical information of any suspicious area
DOT Image Construction – Reconstructs 3D functional images to reflect the spatial distribution of HBT, HBO2, and HB
Quantitative Analysis – Performs quantitative analysis of DOT and ultrasound images to generate a report with BI-Rads rating values

HB Index Chart (8 early stage breast cancer, 57 benign tumor)

Clear Efficacy Indication

The result shows significantly higher HB index values in the malignant group (avg.122µmol/L)than those in the beginning group (avg.55 µmol/L).

When a threshold of 95 is used to separate malignant and benign lesions, the sensitivity specificity values are 100% and 96%.

Optical tomography provides higher sensitivity and higher specificity than color doppler ultrasound.

HB Index Chart

Clinical Trials
Clinical trials were performed in four hospitals in China. The diagnosis result of OPTIMUS system was compared with X-ray mammography and biopsy results. With 90 trial cases, OPTIMUS system demonstrates 100% sensitivity and 86% specificity.

Screening and Diagnosis
OPTIMUS is used in a hospital specializing in tumor as a screening and a patient diagnosis device. Among 833 women examined over a two-month period, 38 were diagnosed as suspicious malignant lesions. 23 out of the 38 patients underwent surgery with 20 confirmed cancer cases.